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Inhibitor Libraries and Pathway Panels

Merck:/topic/images/Biosciences/InhibitorLibrary_spotlightbanner.jpg

 

 

For decades, Calbiochem® has manufactured high quality inhibitors, biochemicals, antibodies, proteins, and kits that have been cited in thousands of peer-reviewed publications. To continue with our endeavor to offer products that fast track your research, we have recently introduced the InhibitorSelect™ Libraries and Signaling Pathway Panels that contain a collection of carefully selected, structurally diverse, and potent inhibitors in convenient and cost effective formats. InhibitorSelect™ products are suitable for a wide variety of applications and are provided with comprehensive documentation.

Product Overview

InhibitorSelect™ Libraries are well-characterized, pharmacologically active, and structurally diverse InSolution™ inhibitors in 96- or 384-well format and offer:

  • Rich and valuable data - Our unique and expert selection of structurally diverse, well-characterized, cell-permeable, and potent inhibitors helps you get the most out of your investment
  • Results the first time, every time - tringent stability and HPLC purity testing on every batch of plates ensures reliable results in every experiment

InhibitorSelect™ Signaling Pathway Panels are 12-16 carefully hand-picked inhibitors in one convenient package to help you elucidate specific steps in a signaling cascade and offer:

  • Experience you can count on - Comprehensive documentation about each inhibitor, such as molecular structure, IC50 values, literature citations, and CAS number (where available), is provided at your fingertips
  • Cost savings - Each panel provides a number of pathway specific inhibitors at a fraction of what it would cost to purchase each inhibitor individually
  • Hassle-free results - Our best selection of inhibitors, a negative control (where applicable), DMSO, and a data sheet are provided in one convenient kit

Sample Applications

The Right Tools for Many Applications – Keep Your Research on the Fast Track

Effective Screening of Inhibitors for Influence on Proliferation and Survival of Mouse Neural Stem Cells

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Rapid Screening of Receptor Tyrosine Kinase (RTK) Inhibition Using InhibitorSelect™ Inhibitor Library I and WideScreen™ RTK pTyr and Total 7-plex Assay Kits on a Luminex® xMAP®Platform.

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Validation & Quality Control

Maximize Your Results and Minimize Your Screening Cost - With Expertly Selected Inhibitors

Inhibitors in each InhibitorSelect™ Library have been expertly selected to ensure structural diversity, cell permeability, reversibility, and potency so that you get the most out of your investment. In addition, the purity of inhibitors provided in each batch of plates is confirmed by HPLC to ensure that you get results the first time and every time. Characteristics of three Akt inhibitors included in InhibitorSelect™ Libraries are shown to demonstrate the diversity and quality of inhibitors provided.

Akt Inhibitor V, Triciribine (Cat. No. 124012)

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Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018)

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Akt Inhibitor X (Cat. No. 124020)

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Inhibitor Library Documentation

Inhibitor Library I 96-Well plate, Cat. No. 539744

Contains 80 inhibitors against mainly tyrosine, AGC and atypical families of kinases

  • Voume: 50 μl/well
  • Concentration: 10mM

Library I-96.sdf (Structure Data Format file, requires special program to open)
Inhibitor Library I-96 List

Inhibitor Library II 96-Well plate, Cat. No. 539745

Contains 80 inhibitors against mainly CMGC and CaMK families of kinases

  • Voume: 50 μl/well
  • Concentration: 10mM

Inhibitor Library II-96.sdf (Structure Data Format file, requires special program to open)
Inhibitor Library II-96 List 

Inhibitor Library III 96-Well plate, Cat. No. 539746

Contains 84 inhibitors against mainly CMGC, CaMK, AGC and STE families of kinases, complementary to 96-well Library II

  • Volume: 50 μl/well
  • Concentration: 10mM

Inhibitor Library III-96.sdf (Structure Data Format file, requires special program to open)
Inhibitor Library III-96 List 

Inhibitor Library I 384-Well plate, Cat. No. 539743

Combines inhibitors from 96-well Library I and II for a total of 160 inhibitors in one 384-well plate

  • Volume: 25 μl/well
  • Concentration: 10 mM

Inhibitor Library I-384.sdf (Structure Data Format file, requires special program to open)
Inhibitor Library I-384 List 

 

Ordering Information

InhibitorSelect™ Libraries

To obtain detailed documentation or Structure Data Format (SDF) files for InhibitorSelect(TM) libraries, please contact Technical Support.

Description 96-well Library I 96-well Library II 96-well Library III 384-well Library I
Size/Format 96-well  96-well  96-well  384-well 
Cat. No.   539744  539745  539746 539743 
ADK X   X  
Akt X   X X
AMPK   X   X
ATM   X   X
ATR   X   X
Aurora X X X X
Bcr-Abl X     X
CaMK   X X X
Cdks   X X X
cFMS X     X
Chk1,2   X X X
CK1,2   X X X
c-Met X     X
DAG X     X
DNA-PK X   X X
eEF2 X   X  
EGFR X     X
ERK   X X X
FLT3 X     X
GSK-3   X X X
IGFR X     X
IKK   X X X
IP3K X   X  
IRAK X     X
JAK X     X
JNK   X   X
LcK X     X
MAPK   X X X
MEK   X X X
MLCK   X X  
MNK1   X   X
p70 S6 X     X
p90 S6 X   X  
PAK X   X  
PDGFR X     X
PDK1 X     X
PI 3-K X   X X
PIKfyve X   X X
PIM X   X  
PKA X   X  
PKC X   X X
PKG X   X  
PKR X     X
PLK X   X  
Rho X   X X
RIP   X X  
SK   X   X
Src X X   X
Syk X X   X
TGF-ΒR X     X
TP-12 X   X  
VEGFR X     X
Wee1 X   X  

 

InhibitorSelect Signaling Pathway Panels

InhibitorSelect™ Pathway Panels contain 12-16 hand-picked inhibitors to help you elucidate specific steps in a signaling cascade. Best of all you’ll save money, since our focused selection of inhibitors is provided to you in one convenient kit at a fraction of what it would cost to purchase each inhibitor individually.

 

Signaling Pathway Panel

PI 3-K/Akt/mTOR

Cat. No. 124031

Components Cat. No.
Akt Inhibitor IV 124011
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
LY 294 440202
LY 303511 440203
PDK1/Akt/Flt Dual Pathway Inhibitor 521275
PI-103 528100
PI 3-Kγ Inhibitor 528106
PI 3-Kγ Inhibitor II 528108
PI 3-Kα Inhibitor IV 528111
PI 3-Kα Inhibitor VIII 528116
Rapamycin 553210
Ro-31-8220 557520
Wortmannin 681675
DMSO KP31817

Signaling Pathway Panel

EGFR

Cat. No. 324839

Components Cat. No.
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
PD 153035 234490
EGFR Inhibitor 324674
Et-18-OCH3 341207
JNK Inhibitor II 420119
LY 294002 440202
PD 98059 513000
PD 168393 513033
PP2 529573
Rapamycin 553210
SB 203580 559389
AG 490 658401
ZM336372 692000
DMSO KP31817

Signaling Pathway Panel

MAP Kinase

Cat. No. 444189

Components Cat. No.
ERK Inhibitor II, FR180204 328007
JNK Inhibitor II 420119
JNK Inhibitor IX 420136
MEK1/2 Inhibitor 444939
MNK1 Inhibitor 454861
MK2a Inhibitor 475863
p38 MAP Kinase Inhibitor V 506156
PD 98059 513000
Raf Kinase Inhibitor IV 553014
SB 203580 559389
Tpl2 Kinase Inhibitor 616373
ZM 336732 692000
DMSO KP31817

Signaling Pathway Panel

NF-κB

Cat. No. 481487

Components Cat. No.
BAY 11-7082 196870
IKK Inhibitor VII 401486
IRAK 1/4 Inhibitor 407601
Histone Acetyltransferase Inhibitor II 382110
Trichostatin A, Streptomyces sp. 647925
MG-132 474790
NEMO Binding Domain Peptide, Cell-Permeable 480025
NF-κB SN50 481480
PD 98059 513000
PDK1/Akt-Flt Dual Pathway Inhibitor 521275
TIRAP Inhibitor Peptide 613570
Tpl2 Kinase Inhibitor 616373
(5Z)-7-Oxozeaenol, Curvularia sp. 499610
JNK Inhibitor II 420119
DMSO KP31817

Signaling Pathway Panel

JAK/STAT

Cat. No. 420138

Components Cat. No.
PD 153035 234490
Indirubin Derivative E804 402081
JAK Inhibitor I 420099
JAK2 Inhibitor II 420132
LY 294002 440202
PP2 529573
SHP1/2 PTPase Inhibitor, NSC-87877 565851
STAT3 Inhibitor Peptide, Cell Permeable 573096
STAT3 Inhibitor III, WP1066 573097
STAT3 Inhibitor V, Statt 573099
STAT5 Inhibitor 573108
AG 490 658401
U0126 662005
DMSO KP31817

 

Signaling Pathway Panel

VEGF

Cat. No. 676502

ComponentsCat. No.
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
Calcineurin Autoinhibitory Peptide, Cell-permeable  207001
ET-18-OCH3 341207
Go 6983 365251
NG-Nitro-L-arginine Methyl Ester, Hydrochloride 483125
p21-Activated Kinase Inhibitor III, IPA-3 506106
cPLA2α Inhibitor 525143
PI-103 528100
PP2 529573
SB 203580 559389
U0126 662005
VEGFR Tyrosine Kinase Inhibitor V 676501
VEGFR2 Kinase Inhibitor VI, Ki8751 676484
VEGFR2 Kinase Inhibitor III, SU5416 676487
ZM 336372 692000
DMSO KP31817

 

Signaling Pathway Panel

Wnt

Cat. No. 681666

ComponentsCat. No.
Casein Kinase I Inhibitor, D4476 218696
Casein Kinase II Inhibitor III, TBCA  218710
β-Catenin/Tcf Inhibitor, FH535 219330
GSK-3 Inhibitor IX 361550
PKG Iα Inhibitor, Cell-Permeable 370655
H-89, Dihydrochloride 371963
JNK Inhibitor II 420119
K-252a, Nocardiopsis sp. 420298
KN-93 422708
LY 294002 440202
(5Z)-7-Oxozeaenol, Curvularia sp. 499610
PP2 529573
Rapamycin 553210
SB 202190 559388
U0126 662005
DMSO KP31817

 

Signaling Pathway Panel

FGF  

Cat. No. 341612

ComponentsCat. No.
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
EGF/FGF/PDGF Receptor Tyrosine Kinase Inhibitor 324841
ET-18-OCH3 341207
FGF/VEGF Receptor Tyrosine Kinase Inhibitor, PD173074 341607
FGF Receptor Tyrosine Kinase Inhibitor 341608
Gö6983 365251
JNK Inhibitor VIII 420135
LY 294002 440202
PD 98059 513000
PP2 529573
Rac1 Inhibitor 553502
STAT3 Inhibitor III, WP1066 573097
U0126 662005
ZM 336372 692000
DMSO KP31817

 

Signaling Pathway Panel

IGF  

Cat. No. 407249

ComponentsCat. No.
AG 1024 121767
Akt Inhibitor IV 124011
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 124018
AMPK Inhibitor, Compound C 171260
bpV(phen) 203695
ERK Inhibitor II, FR180204 328007
GSK-3β Inhibitor VIII 361549
IGF-1R Inhibitor, PPP 407247
NBI-31772 479830
PD 98059 513000
PI-103 528100
PKCβ Inhibitor 539654
Rapamycin 553210
RSK Inhibitor, SL0101 559285
ZM 336372 692000
DMSO KP31817

 

Signaling Pathway Panel

Hedgehog (Hh) 
Cat. No. 373386

ComponentsCat. No.
Smoothened Agonist, SAG 566660
Cyclopamine-KAAD 239804
HH Signaling Antagonist XIV, SANT-2 373273
Hh/Gli Antagonist, GANT61 373401
GSK-3 Inhibitor IX, BIO 361550
H-89, Dihydrochloride 371963
IC261 400090
βARK1 Inhibitor 182200
MG-132 474790
Hh Signaling Antagonist VII, JK184 373385
Purmorphamine 540220
Fluvastatin, Sodium Salt 344095
Hh Signaling Antagonist XII, HPI-1 373275
Hh Signaling Antagonist XIII, HPI-3 373276
DMSO KP31817

 

Signaling Pathway Panel

TGF-βR and BMPR
Cat. No. 616466

ComponentsCat. No.
Akt Inhibitor XIII, Isozyme-Selective, Akti2-1/2 124030
AMPK Inhibitor, Compound C 171260
ET-18-OCH3 341207
IRAK-1/4 Inhibitor 407601
JAK Inhibitor I 420099
MG-132 474790
(5Z)-7-Oxozeaenol, Curvularia sp. 499610
p21-Activated Kinase Inhibitor III, IPA-3 506106
PD 169316 513030
PI-103 528100
Rac1 Inhibitor 553502
Ro-31-8220 557520
Smad3 Inhibitor, SIS3 566405
STAT3 Inhibitor III, WP1066 573097
TGF-β RI Kinase Inhibitor II 616452
TGF-β RI Kinase Inhibitor VI, SB431542 616461
U0126 662005
Y-27632 688000
DMSO  KP31817

 

Signaling Pathway Panel

p53
Cat. No. 506169

ComponentsCat. No.
ATM Kinase Inhibitor 118500
ATM/ATR Kinase Inhibitor 118501
Anacardic Acid 172050
Cdk1 Inhibitor IV, RO-3306 217699
Casein Kinase II Inhibitor III, TBCA 218710
Chk2 Inhibitor II 220486
Hdm2 E3 Ligase Inhibitor 373225
JNK Inhibitor II 420119
MDM2 Antagonist, Nutlin-3, Racemic 444143
MDMX Inhibitor, SJ-172550 444155
MG-132 474790
p21-Activated Kinase Inhibitor III, IPA-3 506106
Pifithrin-α 506132
PI-103 528100
PARP Inhibitor VIII, PJ34 528150
PPM1D Phosphatase Inhibitor 529578
PRIMA-1 530050
Caspase Inhibitor I 627610
Trichostatin A, Streptomyces sp. 647925
DMSO KP31817

 

Product Citations

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